Symbol
Name
ID

Cdk5r1
cyclin dependent kinase 5, regulatory subunit 1
MGI:101764

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

nervous system phenotype

increased susceptibility to pharmacologically induced seizures

seizures

abnormal axon extension

abnormal forebrain development

thin cortical plate

abnormal subplate morphology

abnormal olfactory bulb development

dilated lateral ventricle

decreased corpus callosum size

abnormal forebrain morphology

abnormal striatum morphology

decreased striatum size

abnormal hippocampus morphology

abnormal dentate gyrus morphology

abnormal hippocampus layer morphology

abnormal hippocampus granule cell morphology

abnormal hippocampus pyramidal cell morphology

abnormal cerebral cortex morphology

abnormal cerebral cortex pyramidal cell morphology

abnormal stratification in cerebral cortex

abnormal cerebellum morphology

ectopic Purkinje cell

delaminated Purkinje cell layer

ectopic cerebellar granule cells

abnormal cerebellar molecular layer

abnormal innervation

impaired synaptic plasticity

abnormal excitatory postsynaptic potential

reduced long-term potentiation

abnormal long-term depression

absent long-term depression

reduced long-term depression

Availability

Mouse Genotype

Cdk5r1^tm1Ivi/Cdk5r1^tm1Ivi

Cdk5r1^tm1Lht/Cdk5r1^tm1Lht

Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh

Cdk5r1^tm2.1Lht/Cdk5r1^tm2.1Lht

Cdk5r1^tm2Ohsh/Cdk5r1^tm2Ohsh
Tg(Pcp2-cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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